The Science Behind Rejuran — And Why I Finally Brought It to ReflectorN

By Sunny, Cosmetic Nurse & Founder of ReflectorN

As a nurse with a background in cardiac and critical care, I’m not easily sold on the latest beauty buzzwords. I’ve trained and worked in some of the world’s top hospitals, and science—not trends—is what guides my decisions. So when I first heard about Rejuran, I had my doubts.

“Another injectable claiming to heal everything?” I thought. I’ve seen plenty of overhyped treatments come and go.

But then I did what I always do—I dug into the research. And what I found genuinely surprised me. Not only is Rejuran backed by clinical studies and regenerative medicine research, but it also has roots in wound healing protocols used on war injuries.

That’s when I knew: this wasn’t hype. This was real.

What Exactly Is Rejuran?

Rejuran is an injectable bioremodelling treatment derived from polynucleotides (PN)—fragments of DNA extracted from wild salmon. These aren’t just random DNA pieces. They’re selected for their remarkable biocompatibility with human skin. In other words, your body recognises them as its own, which means better tolerance and better results.

Once injected into the dermis, these polynucleotides begin working at a cellular level to:

• Repair damaged or aged skin tissue

• Stimulate fibroblast activity, boosting natural collagen and elastin production

• Improve hydration, elasticity, and skin texture

• Reduce redness, inflammation, and oxidative stress

• Support skin barrier restoration and healing

Unlike traditional injectables, Rejuran isn’t about creating volume or changing facial structure. It’s about regenerating the skin from within—healing, strengthening, and renewing the skin matrix.

Where Did It Come From? A Wound-Healing Breakthrough

Here’s what truly got my attention: Rejuran’s polynucleotide technology was originally researched and used in the treatment of traumatic war wounds and burn injuries.

Researchers discovered that DNA fragments derived from salmon had profound effects on tissue regeneration and inflammatory control. These fragments helped speed up skin repair, reduce scar formation, and protect surrounding tissues from oxidative damage.

This technology was later adapted for aesthetic use—helping to heal sun-damaged, ageing, or inflamed skin in a way that goes far beyond surface-level skincare.

How Rejuran Works: Breaking It Down

Let’s go deeper. Rejuran primarily works through:

1. Tissue Regeneration

Polynucleotides activate fibroblasts—your skin’s collagen-producing workhorses. This results in smoother, firmer skin over time, not just temporary plumpness.

2. Anti-Inflammatory Action

Rejuran reduces cytokine activity, which helps calm inflammation. This is why it’s great for acne-prone or sensitive skin types.

3. Angiogenesis Support

It improves microcirculation and stimulates the formation of new capillaries, enhancing oxygen and nutrient delivery to the skin.

4. Antioxidant Protection

Polynucleotides help neutralise free radicals, which are one of the main drivers behind ageing and skin cell damage.

5. Enhanced Skin Barrier

Rejuran strengthens the skin barrier by supporting keratinocyte regeneration. This is particularly helpful for skin that's become reactive or compromised due to over-exfoliation, rosacea, or post-treatment stress.

What Rejuran Can Treat

This is not a “one-type-fits-all” injectable. Rejuran is incredibly versatile and ideal for patients who are looking to:

• Improve fine lines and wrinkles, especially around the eyes and mouth

• Strengthen thinning, fragile, or damaged skin

• Improve acne scars or textural irregularities

• Calm redness and rosacea-prone skin

• Rejuvenate tired, dull or post-inflammatory stressed skin

• Support skin recovery after procedures like microneedling or laser

It’s also a fantastic treatment for those who don’t want volume-based filler but still want to achieve rejuvenation and skin correction.

Why I Was Skeptical — And What Changed My Mind

At ReflectorN, I take every product seriously. I ask: Is it safe? Is it backed by evidence? Does it fit with my holistic skin philosophy?

Rejuran initially felt like another trend—but the more I read, the more it aligned with my clinical standards. The war wound research, the molecular biology behind it, the visible improvements in skin quality—it all added up.

What really convinced me was the results I saw in clinical trials and peer-reviewed journals. Unlike many treatments that only offer temporary results, Rejuran restores function to the skin. That’s a game-changer.

What To Expect From Treatment

Rejuran is injected using fine needles or a cannula into the mid-dermis. The treatment is generally well tolerated and may cause some mild swelling or pinpoint bruising, which settles quickly.

For optimal results, a course of 3 treatments spaced 2–4 weeks apart is recommended, followed by maintenance treatments every 6–12 months depending on your skin goals.

You may begin to notice improved texture and glow within a few weeks, with full collagen remodelling and barrier improvement occurring over 2–3 months.

Final Thoughts — Who Is Rejuran Best For?

Rejuran is ideal if:

• Your skin feels fragile, red, reactive or inflamed

• You want to heal rather than just “fill”

• You’ve struggled with acne scars, fine lines, or dull skin

• You’re seeking a regenerative, not artificial, result

• You’ve done “everything else” and want something that treats your skin at the cellular level

Ready To Try Rejuran?

Rejuran isn’t a trend. It’s a clinically backed, biologically active treatment that supports true skin healing. And that’s exactly why I chose to bring it to ReflectorN.

📍 You can now experience Rejuran at our Fairfield clinic, serving Northcote, Thornbury, Ivanhoe, Alphington, and surrounds.

🔗 Book a consultation to see if it’s right for your skin: [www.reflectorn.com.au]📩 Got questions? Send us a message on Instagram @Reflecto_RN